Clustering of 5 1 integrins determines adhesion strength whereas v 3 and talin enable mechanotransduction
نویسندگان
چکیده
منابع مشابه
Cell adhesion to laminin 1 or 5 induces isoform-specific clustering of integrins and other focal adhesion components.
Laminin 1 (alpha1beta1gamma1) and laminin 5 (alpha3beta3gamma2) induce cell adhesion with different involvement of integrins: both are ligands for the alpha6beta1 integrin, while alpha3beta1 integrin has affinity for laminin 5 only. These two laminin isoforms therefore provide good models to investigate whether alpha3beta1 and alpha6beta1 integrins play different roles in signal transduction an...
متن کاملIntegrins in mechanotransduction.
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces. We review the relationship between integrins and mech...
متن کاملForce-induced activation of talin and its possible role in focal adhesion mechanotransduction.
It is now well established that cells can sense mechanical force, but the mechanisms by which force is transduced into a biochemical signal remain poorly understood. One example is the recruitment of vinculin to reinforce initial contacts between a cell and the extracellular matrix (ECM) due to tensile force. Talin, an essential linking protein in an initial contact, contains at least one vincu...
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Recycling endosomes feed autophagy B y identifying a protein that hampers membrane traffi cking within the cell, Longatti et al. provide evidence that recycling endosomes supply membrane to growing autophagosomes. When cells are stressed or hungry, they often eat some of their contents through the process of autophagy, in which a membrane compartment called an autophagosome forms and scoops up ...
متن کاملVinculin, talin, and integrins are localized at specific adhesion sites of malignant B lymphocytes.
The microanatomy of the dot-shaped, close-contact sites called podosomes and the mechanism of their formation have been investigated in vitro in the malignant lymphocytes of B chronic lymphocytic leukemia (B-CLL). In this paper the authors demonstrate that in B-CLL podosomes: (1) vinculin, talin, and beta 2 integrin (CD18) rings surround an F-actin core; (2) the beta 1 integrin is localized wit...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0902818106